REGULAR PHYSICAL ACTIVITY REDUCES THE PERCENTAGE OF SPINALLY PROJECTING NEURONS THAT EXPRESS MU-OPIOID RECEPTORS FROM THE ROSTRAL VENTROMEDIAL MEDULLA IN MICE

Regular physical activity reduces the percentage of spinally projecting neurons that express mu-opioid receptors from the rostral ventromedial medulla in mice

Abstract.Introduction:.Regular physical activity/exercise is an effective nonpharmacological treatment for individuals with chronic pain.Central inhibitory mechanisms, involving serotonin and opioids, are critical to analgesia produced by regular physical activity.The rostral ventromedial medulla (RVM) sends projections to the spinal cord to inhibi

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Study protocol of REpeat versus SIngle ShoT Antibiotic prophylaxis in major Abdominal Surgery (RESISTAAS I): a prospective observational study of antibiotic prophylaxis practice for patients undergoing major abdominal surgery

Introduction Surgical site infections (SSIs) are among the most common complications after abdominal surgery and develop in approximately 20% of patients.These patients suffer a 12% increase in mortality, underlying the need for strategies reducing SSI.Perioperative antibiotic prophylaxis is paramount for SSI prevention in major abdominal surgery.Y

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